Dorzolamide/timolol (Into the eye)


Dorzolamide Hydrochloride (dor-ZOLE-a-mide hye-droe-KLOR-ide), Timolol Maleate (TIM-oh-lol MAL-ee-ate)

Treats increased eye pressure caused by glaucoma or hypertension of the eye.

Brand Name(s)

Cosopt Ocumeter Plus, Cosopt PF

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to dorzolamide or timolol, or to sulfa drugs or beta blockers. Do not use this medicine if you have asthma or COPD, heart failure, slow heartbeat, or certain heart rhythm problems.

How to Use This Medicine

Liquid, Drop

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • Wash your hands with soap and water before and after using this medicine.
  • Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.
  • To use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.
  • Allow 5 or 10 minutes to pass between using this medicine and using any other medicines in your eyes (drops or ointment).
  • Use only the brand of this medicine that your doctor prescribed. This product is marketed with (Cosopt®) and without preservative (Cosopt® PF).
  • Cosopt®: Remove contact lenses before using this medicine. Wait at least 15 minutes before putting the contact lenses back in.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the Cosopt® PF single-use containers in the original pouch to protect from light. Write down the date you open the foil pouch in the space provided. Throw away any unused medicine 15 days after opening the pouch.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine container and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using acetazolamide (Diamox®), aspirin, clonidine (Catapres®), digoxin (Lanoxin®), injectable epinephrine (EpiPen®), methazolamide (Neptazane®), quinidine (Cardioquin®, Quinaglute®), reserpine, insulin or diabetes medicine that you take by mouth (such as glipizide, Actos®, or Glucotrol®), or medicine to treat depression (such as fluoxetine, paroxetine, Celexa®, Prozac®, or Zoloft®). Tell your doctor if you use blood pressure medicine such as amlodipine (Norvasc®), amlodipine/benazepril (Lotrel®), atenolol (Tenormin®), diltiazem (Cardizem®, Tiazac®), metoprolol (Lopressor®, Toprol®), nadolol (Corgard®), nifedipine (Procardia®), propranolol (Inderal®), or verapamil (Calan®, Isoptin®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, diabetes, thyroid problems, or myasthenia gravis. Tell your doctor if you are allergic to sulfa drugs.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
  • Tell your doctor right away if your eyes or eyelids become red, itchy, or swollen when you use the drops.
  • Tell your doctor right away if you have black or tarry stools, blistering or peeling skin, dark urine, unusual bleeding or bruising, or yellow eyes or skin.
  • Call your doctor right away if you have an injury to your eye, an eye infection, or if you need to have surgery on your eye.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Chest pain
  • Dark-colored urine or pale stools
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Redness, itching, or swelling of your eye or eyelids
  • Severe muscle weakness
  • Shortness of breath, cold sweat, and bluish skin
  • Slow heartbeat, lightheadedness, or fainting
  • Sores, ulcers, or white patches in your mouth
  • Unusual bleeding, bruising, or weakness
  • Yellowing of your skin or the whites of your eyes

If you notice these less serious side effects, talk with your doctor:

  • Bitter or unusual taste in your mouth
  • Blurred vision, cloudy vision, or dry eyes

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

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