Dornase alfa (By breathing)


Dornase Alfa (DOR-nase AL-fa)

Treats cystic fibrosis.

Brand Name(s)


When This Medicine Should Not Be Used

How to Use This Medicine


  • Use your medicine as directed.
  • You will use this medicine with an inhaler device called a nebulizer. The nebulizer turns the medicine into a fine mist that you breathe in through your mouth and to your lungs. Your caregiver will show you how to use your nebulizer.
  • Do not mix any other medicine in the nebulizer with dornase alfa.
  • This medicine comes in single-dose ampules (vials). Once an ampule has been opened, you must use all of the medicine in it. Do not save an opened ampule for later use.
  • Missed dose: Use your medicine as soon as you remember. If it is almost time for your next dose, wait until then and use a regular dose. Do not use extra medicine to make up for a missed dose.
  • Store the medicine in the refrigerator in its foil pouch and protect it from direct light. Do not freeze. Do not leave the medicine at room temperature for more than 24 hours.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Cough, runny nose, sore throat
  • Voice changes

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 7/4/2015

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission ( URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.