Debriding agent (On the skin)


Cleans and treats certain types of wounds.

Brand Name(s)

AllanZyme, Allanfil, Allanfil 405 Ointment, Allanzyme 650 Ointment, Ethezyme 830 Papain, Granulex, Optase, Santyl, TBC

When This Medicine Should Not Be Used

How to Use This Medicine

Foam, Spray, Liquid, Ointment, Gel/Jelly

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Wash your hands with soap and water before and after you use this medicine. This medicine should only be used on your skin. Do not get this medicine in your eyes, nose, or mouth.
  • Before using a new spray bottle, prime the pump by holding the spray upright directly over the wound, and pumping 6 to 8 times.
  • Once the spray pump has been primed, hold the bottle about 2 to 3 inches from your wound to apply. Use even, firm, and equal pressure each time you pump the bottle. Completely cover your wound site with the medicine. You should not be able to see the wound under the medicine. Then, follow your doctor's directions for dressing (covering) the wound.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store this medicine at room temperature, away from heat, cold, or fire. Keep the container opening covered and clean when you are not using it. Store the spray upright.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Ask your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Avoid using medications on your wound that contain metals such as lead, silver, and mercury. Make sure your doctor knows about all other medicine and wound treatments you are using.
  • Do not use hydrogen peroxide on your wound when using this medicine, unless your doctor tells you to.

Warnings While Using This Medicine

  • Follow your doctor's instructions about how to care for your wound before and after using this medicine.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Burning or irritation of the wound.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 12/4/2015

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission ( URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.