Danazol (By mouth)

Introduction

Danazol (DAN-a-zol)

Treats endometriosis, fibrocystic breast disease, and hereditary angioedema.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to danazol. You should not use this medicine if you have severe liver disease, kidney disease, heart disease, or a history of blood clotting problems. Do not use this medicine if you have a tumor that is sensitive to androgen (male hormone) or porphyria. Do not use this medicine if you are pregnant or breastfeeding or if you have unusual vaginal bleeding that has not been checked by your doctor.

How to Use This Medicine

Capsule

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • You should start taking this medicine while you are having your monthly period.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use carbamazepine (Tegretol®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), tacrolimus (Prograf®), insulin or diabetes medicine that you take by mouth (such as glyburide, metformin, Actos®, or Glucotrol®), medicine to lower cholesterol (such as atorvastatin, lovastatin, simvastatin, Lipitor®, Mevacor®, or Zocor®), or a blood thinner (such as warfarin, Coumadin®).

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. Your doctor may give you a pregnancy test before you start this medicine to make sure you are not pregnant. You should use birth control that does not have hormones while you take this medicine.
  • Make sure your doctor knows if you have a blood disease, diabetes, epilepsy, high blood pressure, kidney or heart problems, or migraines.
  • This medicine may cause irregular or absent monthly periods. Check with your doctor if your monthly period does not begin within 60 to 90 days after you stop taking this medicine.
  • Women should check with their doctor right away if they develop a deep or husky voice, have unusual hair growth, or gain weight.
  • Check with your doctor right away if you have vision changes, headache, nausea, or vomiting. These may be symptoms of a serious condition called benign intracranial hypertension.
  • This medicine may affect blood sugar levels. Check with your doctor if you notice a change in the results of your blood or urine sugar tests.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
  • This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing, or sudden weakness or numbness
  • Dark-colored urine or pale stools
  • Headache or changes in vision
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach
  • Swelling of the face, hands, arms, legs, or feet

If you notice these less serious side effects, talk with your doctor:

  • Acne, oily skin, deep or husky voice, or new growth of facial or body hair
  • Weight gain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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