Crizotinib (By mouth)

Introduction

Crizotinib (kriz-OH-ti-nib)

Treats advanced or metastatic non-small cell lung cancer (NSCLC).

Brand Name(s)

Xalkori

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to crizotinib, or if you are pregnant.

How to Use This Medicine

Capsule

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • You may also receive medicines to help prevent nausea and vomiting.
  • You may take this medicine with or without food.
  • Swallow the capsule whole. Do not break, crush, chew, or open it.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose. If you miss a dose or forget to use your medicine, use it as soon as you can. If your next regular dose is less than 6 hours away, wait until then to use the medicine and skip the missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the capsules in its original container.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using medicine to treat HIV/AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Fortovase®, Invirase®, Norvir®, or Viracept®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, telithromycin, troleandomycin, voriconazole, Biaxin®, Ketek®, Nizoral®, or Sporanox®), medicine to treat tuberculosis (such as rifabutin, rifampin, Mycobutin®, Rifadin®, or Rimactane®), medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, Luminal®, or Tegretol®), medicine to treat depression (such as nefazodone, Serzone®), or St. John's wort.
  • Tell your doctor if you are also using arsenic trioxide (Trisenox®), cisapride (Propulsid®), dofetilide (Tikosyn®), medicine for depression (such as amitriptyline, fluoxetine, nortriptyline, Elavil®, Pamelor®, Prozac®, Sarafem®, or Vivactil®), certain antibiotics (such as erythromycin, levofloxacin, moxifloxacin, sparfloxacin, Avelox®, Levaquin®, or Zagam®), or medicine to treat mental illness (such as haloperidol, mesoridazine, pimozide, prochlorperazine, quetiapine, thioridazine, ziprasidone, Compazine®, Geodon®, Haldol®, Mellaril®, Orap®, Serentil®, or Seroquel®).
  • Make sure your doctor knows if you are also using alfentanil (Alfenta®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), fentanyl (Sublimaze®), quinidine (Cardioquin®, Quinaglute®), sirolimus (Rapamune®), tacrolimus (Prograf®), or ergot medicines (such as dihydroergotamine, ergotamine, D.H.E.® 45, Ergomar®, Ergostat®, or Migranal®).
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine

  • Your unborn baby could be harmed if you use this medicine while you are pregnant. Use an effective form of birth control to keep from getting pregnant. Tell your doctor right away if you think you have become pregnant while using the medicine.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, congestive heart failure, heart rhythm problems (such as congenital long QT syndrome, slow heartbeat), or mineral imbalance.
  • This medicine may cause swelling of the lungs (pneumonitis). Pneumonitis is a life-threatening condition and requires immediate medical attention. Stop using this medicine and check with your doctor right away if you have a cough with or without mucous, shortness of breath, troubled breathing, or a fever.
  • Check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • This medicine can change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or uneven heartbeats.
  • Cancer medicines can cause constipation, diarrhea, nausea, or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • This medicine may cause dizziness, tiredness, blurred vision, or other vision problems. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert or not able to see well. Check with your doctor if these visual changes occur. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
  • Do not change your dose or stop using this medicine without first checking with your doctor.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain.
  • Cough with or without mucous.
  • Dark-colored urine or pale stools.
  • Fast, pounding, or uneven heartbeat.
  • Fever, chills, runny or stuffy nose, sore throat, and body aches.
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Rapid weight gain.
  • Shortness of breath or troubled breathing.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Back, muscle, or joint pain.
  • Blurred vision, double vision, or changes in vision.
  • Change or loss of taste.
  • Decreased appetite.
  • Diarrhea, constipation, nausea, vomiting, heartburn, stomach pain, or upset stomach.
  • Headache or dizziness.
  • Rash.
  • Seeing floating dark spots or material before the eyes.
  • Sores or white patches on your lips, mouth, or throat.
  • Tiredness.
  • Trouble sleeping.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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