Clomipramine (By mouth)

Introduction

Clomipramine (kloe-MIP-ra-meen)

Treats obsessive-compulsive disorder. This medicine is a tricyclic antidepressant (TCA).

Brand Name(s)

Anafranil

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to clomipramine or similar medicines such as imipramine amitriptyline, nortriptyline, or Elavil®. Do not use this medicine with a MAO inhibitor (MAOI) such as Eldepryl®, linezolid (Zyvox®), Marplan®, methylene blue, Nardil®, or Parnate® or if you have used a MAOI in the past 14 days. Do not use this medicine if you have had a recent heart attack.

How to Use This Medicine

Capsule, Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • Your doctor may tell you to take the medicine at bedtime to prevent drowsiness during the day.
  • It is best to take this medicine with food or milk.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you use buspirone (Buspar®), cimetidine (Tagamet®), clonidine (Catapres®), digoxin (Lanoxin®), fentanyl (Abstral®, Duragesic®), guanethidine (Ismelin®), haloperidol (Haldol®), lithium (Eskalith®, Lithobid®), methylphenidate (Ritalin®), St John's wort, tryptophan, thyroid medicines, pain or migraine medicines (such as sumatriptan, tramadol, Frova®, Maxalt®, Relpax®, Zomig®), or a phenothiazine medicine (such as promethazine, Phenergan®, Thorazine®). Tell your doctor if you also use medicines to treat depression (such as fluoxetine, fluvoxamine, paroxetine, sertraline), medicines to treat seizures (such as phenobarbital, phenytoin, Dilantin®), medicines for heart rhythm problems (such as flecainide, propafenone, quinidine, Rythmol®, Tambocor®), or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
  • Tell your doctor if you use a medicine to treat incontinence or a medicine that can cause dry mouth or constipation (such as atropine, dicyclomine, glycopyrrolate, scopolamine, Bentyl®, Robinul®, Transderm Scop®).
  • Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding or if you have liver disease, an adrenal gland tumor (such as neuroblastoma, pheochromocytoma), narrow-angle glaucoma, heart disease, depression, mood or mental problems, an overactive thyroid, trouble passing urine, or a history of seizures.
  • For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or are getting worse quickly. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
  • Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.
  • This medicine may make you dizzy or drowsy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine may cause men to have problems with sex. Check with your doctor if you have problems with ejaculation or decreased sexual performance or desire.
  • Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Agitation, anxiety, confusion, depression, irritability, memory problems, trouble sleeping
  • Change in how much or how often you urinate, painful or difficult urination
  • Chest pain
  • Fast, pounding heartbeat
  • Increased sweating, warmth or redness in your face, neck, arms, or upper chest
  • Lightheadedness, dizziness, fainting
  • Seizures or tremors
  • Unusual behavior or thoughts of hurting others or yourself
  • Unusual bleeding, bruising, or weakness
  • Unusual drowsiness or sleepiness

If you notice these less serious side effects, talk with your doctor:

  • Changes in vision or taste, dry mouth
  • Cough, sore throat, runny or stuffy nose
  • Headache
  • Nausea, vomiting, diarrhea, constipation, loss of appetite, stomach pain or upset
  • Problems with sex
  • Skin rash or itching
  • Tiredness
  • Weight changes

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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