Chloroprocaine (Injection)


Chloroprocaine (klor-oh-PROE-kane)

Used before surgery to numb your skin or some parts of your body. This medicine is a local anesthetic.

Brand Name(s)

Nesacaine, Nesacaine-MPF

When This Medicine Should Not Be Used

How to Use This Medicine


  • This medicine will be injected through a needle into your back (spinal cord) before a surgery.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how chloroprocaine works. Tell your doctor if you are taking any of the following:
    • Blood pressure medicine
    • Depression medicine
    • Ergot medicine
    • MAO inhibitor (MAOI)
    • Phenothiazine, such as promethazine, chlorpromazine
    • Sulfonamide

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart rhythm problems, high or low blood pressure, or a lung, liver, or nerve disease.
  • This medicine will temporarily numb your skin or a part of your body. Be careful not to injure the treated area. You may also have trouble walking.
  • If you receive this medicine during childbirth, your baby may be sleepy or have muscle weakness for the first day or two after birth.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, dizziness, ringing in your ears, depression, or drowsiness
  • Change in how much or how often you urinate
  • Fainting or lightheadedness
  • Fast, slow, or uneven heartbeat
  • Fever or increased sweating
  • Loss of movement of any part of your body
  • Tremors or seizures

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 7/4/2015

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