Carfilzomib (Injection)

Introduction

Carfilzomib (kar-FILZ-oh-mib)

Treats multiple myeloma (a type of bone marrow cancer).

Brand Name(s)

Kyprolis

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to carfilzomib, or if you are pregnant.

How to Use This Medicine

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.
  • You may be given medicine to help prevent reactions to the injection.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, peripheral neuropathy (a nerve problem), low blood platelet levels, or a history of herpes zoster infection (shingles).
  • This medicine may cause heart problems. Make sure your doctor knows if you already have heart failure, angina, heart rhythm problems, or a history of heart attack. Tell your doctor if you start to have chest pain, shortness of breath, uneven heartbeat, or swelling of the feet, ankles, or legs.
  • This medicine may cause a serious reaction called tumor lysis syndrome (TLS). Call your doctor if you have a change in how much or how often you urinate, rapid weight gain, muscle or joint pain, swelling of the feet or lower legs, or unusual tiredness.
  • This medicine may cause lightheadedness, dizziness, or tiredness. Stand or sit up slowly if you are dizzy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • Check with your doctor if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be signs of a serious liver problem.
  • Call your doctor if you have an infusion reaction, which could happen as long as 24 hours after each dose. The symptoms of an infusion reaction include fever, chills, joint or muscle pain, redness or warm feeling in your face, swelling of your face, vomiting, trouble breathing, weakness, chest pain or tightness, or feeling lightheaded, dizzy, or faint.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, painful or difficult urination
  • Chest pain or discomfort, uneven heartbeat
  • Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fever, chills, cough, sore throat, and body aches
  • Lightheadedness, dizziness, or fainting
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Rapid weight gain, swelling of your hands, ankles, or feet
  • Trouble breathing, cold sweats, bluish-colored skin
  • Unusual bleeding, bruising, tiredness, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, constipation
  • Headache, back pain
  • Runny or stuffy nose

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

         
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