Captopril/hydrochlorothiazide (By mouth)

Introduction

Captopril (KAP-toe-pril), Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide)

Treats high blood pressure (hypertension). This medicine is a combination of an ACE inhibitor and a thiazide diuretic.

Brand Name(s)

Capozide 25/15, Capozide 50/25

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to captopril or hydrochlorothiazide. Do not use this medicine if you are allergic to sulfa drugs, or other blood pressure medicines such as enalapril, lisinopril, Accupril®, Altace®, Lotensin®, Lotrel®, Monopril®, Prinivil®, Vasotec®, or Zestril®. Do not use this medicine if you are pregnant, or if you have problems urinating.

How to Use This Medicine

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • It is best to take this medicine on an empty stomach, 1 hour before you eat a meal.
  • Be sure to drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting. Most adults should drink at least 6 to 8 (eight-ounce) cups of water each day.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • There are many other drugs that can interact with captopril/hydrochlorothiazide. Make sure your doctor knows about all other medicines you are using, especially any other blood pressure medicines or diuretics ("water pills"). Examples of diuretics include furosemide, hydrochlorothiazide, spironolactone, triamterene, Aldactone®, Dyrenium®, Dyazide®, Hyzaar®, Lasix®, Maxzide®, Midamor®, and Moduretic®.
  • You should not use lithium together with captopril/hydrochlorothiazide, unless your doctor tells you to.
  • Do not use potassium supplements or salt substitutes that contain potassium without asking your doctor.
  • Avoid using narcotic pain relievers, phenobarbital, or other sedatives.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breast feeding, or if you have lupus, scleroderma, polychondritis, or Behcet's syndrome. Tell your doctor if you have asthma, allergies, congestive heart failure, gout, diabetes, liver disease, or kidney disease, or if you are on dialysis.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
  • Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, fast or pounding heartbeat.
  • Confusion, weakness, irregular heartbeat, shortness of breath, or numbness or tingling in your hands, feet, or lips.
  • Dark-colored urine or pale stools, loss of appetite, pain in your upper stomach.
  • Dry mouth, increased thirst, muscle cramps, nausea or vomiting.
  • Fever, chills, cough, sore throat, and body aches.
  • Increase in how much or how often you urinate.
  • Lightheadedness or fainting.
  • Yellowing of your skin or the whites of your eyes.
  • Rapid weight gain, swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Cough.
  • Hot, dry skin.
  • Increased sweating.
  • Mild skin rash.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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