Bupivacaine/epinephrine (Injection)


Bupivacaine (bue-PIV-a-kane), Epinephrine (ep-i-NEF-rin)

This medicine is a local anesthetic that causes numbness (loss of feeling) in the mouth. Given before and during dental work to help prevent pain.

Brand Name(s)

Sensorcaine-MPF With Epinephrine, Marcaine w/ Epinephrine, Marcaine Epi, Marcaine HCl/Epinephrine, Sensorcaine With Epinephrine, Marcaine with Epinephrine

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to bupivacaine, epinephrine, sulfites, or certain other types of local anesthetic (numbing medicine).

How to Use This Medicine


  • A nurse or other trained health professional will give you this medicine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you are using a MAO inhibitor (MAOI) medicine such as Eldepryl®, Marplan®, Nardil®, or Parnate®.
  • Tell your doctor if you are using medicine to treat nausea and vomiting, pain, nervousness, or anxiety. Let your doctor know if you are using medicine such as haloperidol (Haldol®) to treat psychiatric (mental) problems. Make sure your doctor knows if you are also using ergot medicine or other medicines for headaches or migraines, such as Cafergot® or Ergomar®. Tell your doctor if you are using medicine to treat depression such as amitriptyline (Elavil®), nortriptyline (Pamelor®), or imipramine (Tofranil®). Make sure your doctor knows about any other medicine you have used recently.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have diabetes, asthma, or thyroid problems. Tell your doctor if you have a history of stroke.
  • Make sure your doctor knows if you have heart disease, high blood pressure, low blood pressure, atherosclerosis (hardening of the arteries), or other circulation problems. Tell your doctor if you have liver disease, or any other health problems or drug allergies you may have.
  • Numbness may last for several hours after using this medicine. There is an increased risk of injury to your tongue, lips, and the inside of your cheeks until this medicine wears off. To avoid injury, do not chew solid foods until normal feeling has returned to the area. Do not test the feeling in your mouth by biting or poking at your tissues.
  • If your child is to receive this medicine, make sure your doctor knows if your child is under the age of 12 years old.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dizziness, drowsiness, confusion (trouble thinking), seizures (convulsions), or fainting.
  • Nausea or vomiting.
  • Restlessness, anxiety.
  • Ringing in the ears.
  • Skin rash.
  • Sudden or severe headache, or problems with vision, speech, or walking.
  • Tremors, shaking, or chills.
  • Uneven, pounding, fast, or slow heartbeats.

If you notice these less serious side effects, talk with your doctor:

  • Swelling near the injection site.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch)

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

This page was last updated: June 18, 2013

Average rating (0)