Boceprevir (By mouth)


Boceprevir (boe-SE-pre-vir)

Used with peginterferon alfa (Pegasys®, Pegintron®) and ribavirin (Copegus®, Rebetol®) to treat hepatitis C.

Brand Name(s)


There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to boceprevir. Do not use this medicine if you are pregnant or if your sexual partner is pregnant.Do not use this medicine together with the following medicines: alfuzosin (Uroxatral®), cisapride (Propulsid®), drospirenone (Yasmin®, Yaz®), oral midazolam (Versed®), pimozide (Orap®), rifampin (Rifadin®, Rimactane®), sildenafil (Revatio®), St John's wort, tadalafil (Cialis®), triazolam (Halcion®), certain medicines to lower cholesterol (such as lovastatin, simvastatin, Zocor®), medicines to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, Tegretol®), or ergot medicines (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine, Ergomar®). Using boceprevir with any of these medicines can cause very serious medical problems.

How to Use This Medicine


  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • Use all of the medicines your doctor has prescribed to treat hepatitis C infection. Boceprevir by itself will not treat hepatitis C.
  • It is best to take this medicine with food or milk.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

If a dose is missed:

  • If you miss a dose or forget to use it and it is less than 2 hours before your next dose, wait until then to take the medicine and skip the missed dose. If you miss a dose and it is more than 2 hours before your next dose, go ahead and take the missed dose and then take the next dose as scheduled. Ask your pharmacist or doctor if you have any questions about this.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container in the refrigerator. You may also store it at room temperature, away from heat, moisture, and direct light for 3 months.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use digoxin (Lanoxin®), medicine for heart rhythm problems (such as amiodarone, bepridil, flecainide, propafenone, quinidine, Cardioquin®, Cordarone®, Quinaglute®, Rythmol®, Tambocor®), certain blood pressure medicine (such as amlodipine, felodipine, nicardipine, nifedipine, nisoldipine, Cardene®, Norvasc®), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, posaconazole, voriconazole, Nizoral®), or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
  • Tell your doctor if you also use alprazolam (Xanax®), bosentan (Tracleer®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), methadone (Dolophine®), midazolam injection, sirolimus (Rapamune®), tacrolimus (Prograf®), medicine to treat depression (such as desipramine, escitalopram, trazodone, Desyrel®, Lexapro®), medicine to treat HIV or AIDS (such as atazanavir, darunavir, efavirenz, lopinavir, ritonavir, Kaletra®, Norvir®, Prezista®, Reyataz®, Sustiva®), medicine to treat impotence (such as sildenafil, tadalafil, vardenafil, Cialis®, Levitra®, Viagra®), or birth control pills.
  • Make sure your doctor knows if you also use atorvastatin (Lipitor®), buprenorphine (Buprenex®), colchicine (Colcrys®), pravastatin (Pravachol®), rifabutin (Mycobutin®), salmeterol (Serevent®), or a steroid medicine (such as budesonide, dexamethasone, fluticasone, Rhinocort®).

Warnings While Using This Medicine

  • You must have a negative pregnancy test before you use this medicine. You can harm your unborn baby if you use this medicine while you are pregnant. This medicine may also cause birth defects if the father is using it when his sexual partner becomes pregnant. Tell your doctor right away if a pregnancy occurs.
  • Birth control pills may not work while you use this medicine. Use 2 other forms of birth control to prevent pregnancy during treatment and for 6 months after treatment ends. You should have a pregnancy test every month during treatment.
  • Make sure your doctor knows if you are breastfeeding, or if you have other liver problems, anemia, neutropenia, HIV infection, or have had an organ transplant. Tell your doctor if you plan to have a surgery.
  • Check with your doctor right away if you have chills, headache, pale skin, trouble breathing, or unusual tiredness or weakness. These could be symptoms of anemia.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • Do not change or suddenly stop using this medicine without checking first with your doctor.
  • This medicine will not keep you from giving hepatitis C to other people. Follow your doctor's instructions to prevent the spread of this infection.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever, chills, cough, sore throat, and body aches
  • Pale skin
  • Trouble breathing
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Change or loss of taste, decreased appetite
  • Diarrhea, nausea, vomiting
  • Hair loss
  • Muscle or joint pain
  • Tiredness
  • Trouble sleeping

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

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