Treats chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL).
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not receive this medicine if you have had an allergic reaction to bendamustine or mannitol, or if you are pregnant.
How to Use This Medicine
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
- Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using ciprofloxacin (Cipro®), fluvoxamine (Luvox®), or omeprazole (Prilosec®).
- Avoid smoking while you are using this medicine.
Warnings While Using This Medicine
- Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
- Make sure your doctor knows if you are breastfeeding, or have kidney disease, liver disease, a bone marrow disorder, or any kind of infection.
- This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
- This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash; itching; swelling of the face, tongue, and throat; trouble with breathing; or chest pain after you get the injection.
- This medicine may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount; joint pain, stiffness, or swelling; lower back, side, or stomach pain; a rapid weight gain; swelling of the feet or lower legs; or unusual tiredness or weakness.
- Serious skin reactions may occur with this medicine. Tell your doctor right away if you have blistering, peeling, or a red skin rash after receiving this medicine.
- This medicine may make you feel unusually weak or tired. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
- Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.
- Cancer medicines can cause diarrhea, nausea, or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash.
- Change in how much or how often you urinate.
- Chest pain.
- Dry mouth, increased thirst, muscle cramps, nausea, or vomiting.
- Fast, pounding, or uneven heartbeat.
- Fever, chills, cough, sore throat, and body aches.
- Joint pain, stiffness, or swelling.
- Lightheadedness or fainting.
- Lower back or side pain.
- Pain, itching, burning, swelling, or a lump under your skin where the needle is placed.
- Painful cold sores or blisters on lips, nose, eyes, or genitals.
- Painful or difficult urination.
- Rapid weight gain.
- Shortness of breath or troubled breathing.
- Swelling in your hands, ankles, or feet.
- Unusual bleeding or bruising.
- Unusual tiredness or weakness.
If you notice these less serious side effects, talk with your doctor:
- Decreased weight.
- Diarrhea, constipation, loss of appetite, or upset stomach.
- Mild skin rash or itching.
- Stuffy or runny nose.
- Trouble with sleeping.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last Reviewed on 06/12/2013
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This page was last updated: September 18, 2013