Aspirin (Rectal)


Aspirin (AS-pir-in)

Treats minor aches, pains, headache, and fever in people who cannot take aspirin by mouth.

Brand Name(s)

When This Medicine Should Not Be Used

How to Use This Medicine


  • Take your medicine as directed.
  • Follow the instructions on the medicine label if you are using this medicine without a prescription.
  • Never take rectal suppositories by mouth.
  • Wash your hands with soap and water before and after using this medicine. Remove the foil or wrapper from the suppository before inserting it.
  • Lie on your left side with your left leg straight or slightly bent, and your right knee bent upward. Gently push the pointed end of the suppository into the rectum about 1 inch.
  • Keep lying down for about 15 minutes to keep the suppository from coming out before it melts. Then, wash your hands again.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • You may store the suppositories in the refrigerator, but do not freeze them.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Aspirin can cause stomach bleeding. Drinking alcohol can make this worse. If you regularly drink 3 or more alcoholic drinks every day, do not take aspirin without asking your doctor. One alcoholic drink is the same as 4 ounces of wine, 12 ounces of beer, or 1 ounce of hard liquor (gin, whiskey, and others).
  • Make sure your doctor knows if you are using a blood thinner such as warfarin (Coumadin®), or if you are using a pain or arthritis medicine (sometimes called "NSAIDs") such as ibuprofen, naproxen, Advil®, Aleve®, Bextra®, Celebrex®, or Motrin®.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have asthma, kidney problems, or a history of ulcers.
  • Aspirin can cause a rare but serious illness called Reye's syndrome in children and teenagers. If a child has behavior changes along with nausea and vomiting while using this medicine, call the child's doctor right away.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever.
  • Severe nausea or vomiting.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 7/4/2015

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