Apixaban (By mouth)

Introduction

Apixaban (a-PIX-a-ban)

Prevents stroke and blood clots. This medicine is an anticoagulant (blood thinner).

Brand Name(s)

Eliquis

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to apixaban, or if you have active bleeding.

How to Use This Medicine

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • When your supply of this medicine is running low, contact your doctor or pharmacist ahead of time. Do not run out of this medicine.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using ritonavir (Norvir®), St John's wort, medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, rifampin, ritonavir, Nizoral®, Rifadin®, Rimactane®), or medicine to treat seizures (such as carbamazepine, phenytoin, Dilantin®).
  • Make sure your doctor knows if you are also using another blood thinner (such as clopidogrel, heparin, prasugrel, warfarin, Coumadin®, Effient®, Jantoven®, Plavix®), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), or medicine to treat depression (such as citalopram, fluoxetine, sertraline, Cymbalta®, Effexor®, Lexapro®, Pristiq®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, an artificial heart valve, or a history of bleeding problems.
  • Do not suddenly stop using this medicine without asking your doctor. You might have a higher risk of stroke for a short time after you stop using this medicine.
  • This medicine increases your risk of bleeding. You could have serious problems if bleeding cannot be controlled. Tell your doctor right away if you have any unusual bruising or bleeding, including frequent nosebleeds, black or bloody urine or stools, or menstrual periods that are heavier than normal. It may take longer for bleeding to stop if you get hurt.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bleeding that will not stop, or unusually heavy vaginal bleeding
  • Chest pain, trouble breathing
  • Coughing up or vomiting blood or material that looks like coffee grounds
  • Feeling dizzy or faint
  • Joint pain or swelling
  • Red or black, tarry stools
  • Red or pink urine
  • Unusual bleeding, bruising, or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

         
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