Analgesic/antitussive/decongestant/expectorant combination (By mouth)


Treats fever, headache, sore throat, body aches, sneezing, runny and stuffy nose, and cough. May also help to loosen mucus in upper airways.

Brand Name(s)

Duraflu, Day Time, Comtrex Deep Chest Cold, Robitussin Cold Cough & Flu, Phenflu DM, Maxiflu DM, Tylenol Cold Severe Congestion, Rite Aid Multi-Symptom Cold Daytime, Rite Aid Mucus Relief Plus, TopCare Cold Multi-Symptom Severe, Tylenol Cold Head Congestion Severe, Good Sense Cold Daytime Multi-Symptom, Good Neighbor Pharmacy Cold Relief, Good Neighbor Pharmacy Cold Multi-Symptom Severe, Leader Severe Congestion Pain Relief Cold

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to acetaminophen (Tylenol®), or to any other ingredients in the medicine you are using. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years old. Using these medicines in very young children might cause serious or possibly life-threatening side effects.

How to Use This Medicine

Liquid Filled Capsule, Tablet, Capsule, Liquid, Chewable Tablet, Fizzy Tablet

  • Avoid using the medicine at bedtime if it makes you restless.
  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • If you are using this medicine without a prescription, follow the instructions on the medicine label.
  • Completely chew the chewable tablet before swallowing it.
  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • You may need to shake the liquid medicine container before opening it.
  • If the medicine is an effervescent tablet, carefully stir the tablet into at least 4 ounces (1/2 cup) of water. Drink all of it right away.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Keep all medicine away from children and never share your medicine with anyone.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • You should not use this medicine if you are using certain medicines for depression called MAO inhibitors, such as Nardil®, Marplan®, Eldepryl®, or Parnate®.
  • Do not use other medicines that contain acetaminophen, a cough suppressant, a decongestant, or an expectorant while taking this medicine. You may be getting more than a safe amount of these medicines.
  • Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
  • Do not drink alcohol while you are using this medicine.Acetaminophen can damage your liver and alcohol can increase this risk. If you often drink three or more alcoholic drinks every day, do not take any medicines that contain acetaminophen without asking your doctor.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have heart disease, high blood pressure, diabetes, asthma, emphysema or other serious lung problems, an enlarged prostate gland that causes trouble passing urine, or thyroid problems.
  • Make sure your doctor knows if you drink alcohol often.
  • This medicine may make you nervous, dizzy, or unable to sleep. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Children may be more sensitive to this medicine than adults, especially if they take too much of it. Always read the medicine label carefully so you give your child the right amount. Ask your pharmacist or doctor if you are not sure how much medicine to give your child.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • If your symptoms do not improve or if they get worse, call your doctor.
  • Fever that lasts for a long time or a fever that does not go away.

If you notice these less serious side effects, talk with your doctor:

  • Cough that lasts for a long time or a cough that does not go away.
  • New symptoms.
  • Redness of your throat or swelling around your throat.
  • Trouble passing urine.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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