Amphetamine/dextroamphetamine (By mouth)


Treats ADHD. Also treats narcolepsy. This medicine is a stimulant.

Brand Name(s)

Adderall, Adderall XR

When This Medicine Should Not Be Used

How to Use This Medicine

Long Acting Capsule, Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Extended-release capsule:
    • Take the capsule in the morning. You may have trouble falling asleep at night if you take it in the afternoon or evening.
    • Swallow the capsule whole. Do not crush, break, or chew it.
    • You may take the capsule with or without food.
    • If you cannot swallow the capsule, carefully open it and sprinkle the beads over a spoonful of applesauce. Swallow the mixture right away without chewing. Do not store it. Do not crush or chew the beads.
  • Tablet: Take it in the morning and early afternoon. You may have trouble falling asleep if you take it at night.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you are taking an MAO inhibitor (MAOI) or you took an MAOI within the past 14 days.
  • Some medicines and foods can affect how this medicine works. Tell your doctor if you are taking any of the following:
    • Blood pressure medicine
    • Chlorpromazine
    • Cold or allergy medicine that contains a decongestant
    • Lithium
    • Methenamine
    • Seizure medicine
  • Fruit juice, vitamin C, and some medicines can change how this medicine dissolves in your stomach. Tell your doctor if you use an antacid or a stomach medicine (such as lansoprazole, omeprazole, pantoprazole).

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart rhythm problems, high blood pressure, circulation problems, or a history of heart attack or stroke. Tell your doctor if you or anyone in your family has a history of depression, bipolar disorder, suicide, mental illness, or drug or alcohol dependence. Tell your doctor if you have Tourette syndrome or a history of seizures.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • This medicine may cause the following problems:
    • Changes in behavior, or unusual thoughts
    • Raynaud phenomenon (a problem with blood circulation in your fingers or toes)
    • Serious heart or blood vessel problems
    • Slowed growth (in children)
  • This medicine may make you dizzy or cause blurred vision. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision or changes in vision
  • Chest pain, trouble breathing, or fainting
  • Extreme energy or restlessness, mood or mental changes, confusion, agitation, unusual behavior
  • Fever, shaking, or uncontrolled muscle movements
  • Fast, pounding, or uneven heartbeat
  • Seeing, hearing, or feeling things that are not there
  • Seizure

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth, diarrhea, nausea, vomiting, stomach pain
  • Headache or dizziness
  • Loss of appetite, weight loss
  • Trouble sleeping

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 7/4/2015

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission ( URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.