Alpha-1 proteinase inhibitor (Injection)
Alpha-1 Proteinase Inhibitor Human (AL-fa 1 PRO-teen-aze in-HIB-i-ter HUE-man)
Treats emphysema (a lung disorder). Also called alpha 1-PI, alpha-1 antitrypsin, or AAT.
Aralast NP, Zemaira, Prolastin-C, Prolastin
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not receive this medicine if you have had an allergic reaction to alpha-1 proteinase inhibitor (alpha 1-PI). Do not receive this medicine if you have too little immunoglobulin A (IgA) in the body and have antibodies against IgA.
How to Use This Medicine
- A nurse or other trained health professional will give you this medicine.
- Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
- This medicine is usually given once a week on a regular schedule. If you have any questions about this, check with your doctor.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding.
- This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; lightheadedness, dizziness, or fainting; trouble with breathing; trouble with swallowing; or any swelling of your hands, face, or mouth after you receive this medicine.
- Alpha 1-PI is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from alpha 1-PI is very low and has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the manufacture of these medicines. Although the risk is low, talk with your doctor if you have concerns. Your doctor may give you a hepatitis B vaccine before receiving this medicine.
- Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate, painful or difficult urination.
- Chest discomfort.
- Cough, fever, chills, sore throat, and body aches.
- Lightheadedness, dizziness, or fainting.
- Wheezing or chest tightness.
- Worsening of breathing problems.
If you notice these less serious side effects, talk with your doctor:
- Headache or dizziness.
- Muscle or bone pain or discomfort.
- Rash or itching skin.
- Runny or stuffy nose.
- Warmth or redness in your face, neck, arms, or upper chest.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last Reviewed on 06/12/2013
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This page was last updated: June 18, 2013