Acetylcysteine/L-methylfolate/methylcobalamin (By mouth)


Acetylcysteine (a-seet-il-SIS-teen), L-Methylfolate (L-meth-il-FOE-late), Methylcobalamin (METH-il-koe-BAL-a-min)

Used as a dietary supplement for patients with or at risk for memory loss, dementia, Alzheimer's disease, or stroke.

Brand Name(s)

Cerefolin NAC, Alz-Nac, Metafolbic Plus

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to acetylcysteine, L-methylfolate, or methylcobalamin.

How to Use This Medicine


  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using colchicine, cholestyramine, sulfasalazine, colestipol, pyrimethamine, metformin, para-aminosalicylic acid, potassium chloride, nitrous oxide, or nitrates (such as nitroglycerin, Imdur®, Ismo®, or Monoket®). Tell your doctor if you use medicine to treat seizures (such as carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, or valproic acid), medicine to treat pain or inflammation (such as ibuprofen, naproxen, Advil®, Aleve®, or Celebrex®), or medicine to treat an infection (such as trimethoprim/sulfamethoxazole, amoxicillin, penicillin, tetracycline, clindamycin, or metronidazole).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have blood disease, liver disease, heart disease, kidney stones, a history of peptic ulcer disease, or diabetes.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, shortness of breath, or coughing up blood.
  • Difficulty urinating, pain while urinating, or blood in your urine.
  • Feeling of swelling of the entire body.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Pain in the lower back or groin area.
  • Pain in your lower leg (calf).
  • Sudden or severe headache, problems with vision, speech, or walking.

If you notice these less serious side effects, talk with your doctor:

  • Mild headache.
  • Nausea, vomiting, diarrhea, or upset stomach.
  • Skin rash or itching.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission ( URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

This page was last updated: June 18, 2013

Average rating (0)