Possible Interactions with: Vitamin B12 (Cobalamin)
If you are currently being treated with any of the following medications, you should not use vitamin B12 supplements without first talking to your health care provider.
Medications that reduce levels of B12 in the body include:
- Anticonvulsants -- include phenytoin (Dilantin), phenobarbital, primidone (Mysoline)
- Chemotherapy medications -- particularly methotrexate
- Colchicine -- used to treat gout
- Bile acid sequestrants -- used to lower cholesterol; include colestipol (Colestid), cholestyramine (Questran), and colsevelam (Welchol)
- H2 blockers -- used to reduce stomach acid; include cimetidine (Tagamet), famotidine (Pepcid AC), ranitidine (Zantac)
- Metformin (Glucophage) -- medication taken for diabetes
- Proton pump inhibitors -- used to reduce stomach acid; include esomeprazole (Nexium), lansprazole (Prevacid), omeprazole (Prilosec), rabeprazole (Aciphex)
Antibiotics, Tetracycline:Vitamin B12 should not be taken at the same time as tetracycline because it interferes with the absorption and effectiveness of this medication. Vitamin B12 should be taken at different times of the day from tetracycline. (All vitamin B complex supplements act in this way and should be taken at different times from tetracycline.)
In addition, long-term use of antibiotics can deplete vitamin B levels in the body, particularly B2, B9, B12, and vitamin H (biotin), which is considered part of the B complex vitamins.
Antiulcer MedicationsMetformin-containing MedicationsPhenobarbital-containing MedicationsPhenytoin-containing MedicationsTetracycline
Cobalamin; Cyanocobalamin; Vitamin B12 (Cobalamin)
- Last Reviewed on 09/06/2007
- Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.