Goldenseal (Hydrastis canadensis) is one of the most popular herbs in the United States, often combined with echinacea and sold to treat or prevent colds. But there's no evidence that it works. In fact, there's very little scientific evidence that goldenseal works to treat any condition.
Nevertheless, goldenseal is often said to kill bacteria and is sometimes used to treat eye infections, diarrhea, urinary tract infections, canker sores, and vaginitis. A substance in goldenseal, called berberine, does kill some kinds of bacteria and fungus in test tube studies. But scientists don't know if goldenseal would kill any germs in people.
Goldenseal is also popular because of a rumor that taking the herb can help block a positive test for illegal drugs. There's no evidence that it works, and several studies have reported that taking goldenseal does not change the results of a drug test.
Goldenseal is a small plant with a single hairy stem. It has two jagged five-lobed leaves, small flowers, and raspberry-like fruit. The bitter tasting rhizome, or root, is bright yellow or brown, twisted, and wrinkled. Goldenseal can be found growing wild in rich, shady soil in the northern United States. But it is now grown mostly on farms.
What's It Made Of?
Goldenseal contains a compound called berberine that kills many types of bacteria in test tubes, including the ones that cause diarrhea. Berberine also kills a wide range of other types of germs in test tubes, such as those that cause candida (yeast) infections and parasites such as tapeworms and Giardia. Berberine may also activate white blood cells, making them better at fighting infection and strengthening the immune system.
Berberine is sometimes used as an antibiotic, although studies haven't shown whether it works or not in people. It has been studied to treat H. pylori infection (the bacterium that causes ulcers) and infectious diarrhea. It is sometimes recommended to treat urinary tract infections (UTIs). Berberine may also be useful in heart failure. However, some experts think the berberine in goldenseal isn't absorbed very well when it's taken by mouth.
Medicinal Uses and Indications
ANTIBIOTIC OR IMMUNE BOOSTER
Today, goldenseal is sold to help with digestion, soothe an upset stomach, and to kill bacteria. It is considered a natural antibiotic and is often combined with echinacea and promoted as strengthening the immune system. However, only one study found that goldenseal might help boost white blood cells (a measure of the infection fighting ability of the immune system), and the study wasn't well designed.
UPPER RESPIRATORY PROBLEMS
Goldenseal is often found in herbal remedies for hay fever (allergic rhinitis), colds, and the flu. There's no real evidence that it works to treat upper respiratory infections or allergies in humans, however. It may help ease a sore throat, which often accompanies cold or flu.
Because goldenseal seems to have antiseptic properties in test tubes, it is sometimes used to disinfect cuts and scrapes.
It is commonly used to treat several skin, eye, and mucous membrane problems, such as sinusitis, pink eye, and urinary tract infections. It is also available in mouthwashes for sore throats and canker sores.
Not many scientific studies have looked at goldenseal. Some have looked at berberine, one of the active compounds in goldenseal. Berberine is widely used in Traditional Chinese Medicine to treat dysentery and infectious diarrhea. Berberine may work in humans to treat malaria, heart failure, and some types of infections, including upper respiratory problems. It may also dilate blood vessels and help treat heart failure. However, oral goldenseal has only very small amounts of berberine. So it is impossible to say whether or not goldenseal would work to treat these conditions.
Goldenseal is available in tablets and capsules (containing the powdered root), liquid extracts, and glycerites (low alcohol extracts). Goldenseal is often combined with echinacea.
How to Take It
Goldenseal is not recommended for children unless your doctor says so. Never give goldenseal to an infant.
For adult use, goldenseal can be taken by mouth. It is often mixed with water and other liquids to create different skin washes, mouthwash, and even as a vaginal douche. Ask your health care provider to find the right kind and dose for you.
The use of herbs is a time honored approach to strengthening the body and treating disease. Herbs, however, contain components that can trigger side effects and interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider qualified in the field of botanical medicine.
Pregnant or breastfeeding women should not use goldenseal.
People with high blood pressure, liver disease, or heart disease should ask their doctor before taking goldenseal.
Goldenseal can irritate the skin, mouth, throat, and vagina. It may also cause an increased sensitivity to sunlight.
Goldenseal may interfere with some medications. If you are taking prescription or over-the-counter medications, ask your doctor before taking goldenseal.
It's possible that berberine (a major component of goldenseal) and goldenseal itself may interact with many medications, including some that are broken down by the liver and some that are affected by a cell protein. For that reason, anyone who takes any prescription or over-the-counter medication should check with their doctor before taking goldenseal.
Cyclosporine: Goldenseal may cause levels of cyclosporine in the body to get too high.
Digoxin: Goldenseal may raise blood levels of digoxin, a medication used to treat heart conditions. This can increase the risk of side effects.
Tetracycline: One study reported that berberine may cause tetracycline antibiotics to not work as well.
Anticoagulants (blood thinners): Theoretically, goldenseal and berberine could increase the risk of bleeding, especially if you take blood thinners. Some blood thinners include:
Other drugs -- Goldenseal may interact with many medications, including:
- Some chemotherapy drugs
- Some drugs to treat HIV
- Amitriptyline (Elavil)
- Cimetidine (Tagamet)
- Cisapride (Propulsid)
- Clarithromycin (Biaxin)
- Diltiazem (Cardizem)
- Donepezil (Aricept)
- Fexofenadine (Allegra)
- Fluoxetine (Prozac)
- Indinavir (Crixivan)
- Loperamide (Imodium)
- Lovastatin (Mevacor)
- Metoprolol (Lopressor, Toprol XL)
- Olanzapine (Zyprexa)
- Ranitidine (Zantac)
- Sildenafil (Viagra)
- Tramadol (Ultram)
- Trazodone (Desyrel)
- Triazolam (Halcion)
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Eye balm; Ground raspberry; Indian paint
- Last Reviewed on 03/17/2013
- Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.
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This page was last updated: May 7, 2013