Cholesterol-lowering medications - HMG-CoA reductase inhibitors (statins)

Medications

  • Atorvastatin
    • Lipitor
  • Fluvastatin
    • Lescol
    • Lescol XL
  • Lovastatin
    • Mevacor
  • Pravastatin
    • Pravachol
  • Simvastatin
    • Zocor

Depletions

Coenzyme Q10

A deficiency of the antioxidant coenzyme Q10 may be associated with long-term conditions including heart disease and high blood pressure. Symptoms of deficiency include gingivitis and weakened immune function. The major symptom of coenzyme Q10 depletion due to statin drugs include muscle aches and weakness.

Editorial Note

The information presented here covers some of the nutrients that may be lowered when you take certain medications. The signs and symptoms listed can be caused by other conditions. If you have these signs and symptoms, it doesn't always mean you have low levels of these nutrients. Many things affect the level of nutrients, including your medical history, diet, and lifestyle, as well as how long you have been taking the medication. Please talk with your health care provider. He or she can best address your health care needs and see if you are at risk for low levels of any nutrients.

Supporting Research

Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician. 2005;72(6):1065-70.

Chu CS, Kou HS, Lee CJ, Lee KT, Chen SH, Voon WC, Sheu SH, Lai WT. Effect of atorvastatin withdrawal on circulating coenzyme Q10 concentration in patients with hypercholesterolemia. Biofactors. 2006;28(3-4):177-84.

Keith M, Mazer CD, Mikhail P, Jeejeebhoy F, Briet F, Errett L. Coenzyme Q10 in patients undergoing CABG: Effect of Statins and Nutritional Supplementation. Nutr Metab Cardiovasc Dis. 2008;18(2):105-11.

Littarru GP, Langsjoen P. Coenzyme Q10 and statins: biochemical and clinical implications. Mitochondrion. 2007;7 Suppl:S168-74.

Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007;37(1):31-7.

Marcoff L, Thompson PD. The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol. 2007;49(23):2231-7.

Pepe S, Marasco SF, Haas SJ, Sheeran FL, Krum H, Rosenfeldt FL. Coenzyme Q10 in cardiovascular disease. Mitochondrion. 2007;7 Suppl:S154-67.

Pelton R, LaValle J, Hawkins EB, et al. Drug Induced Nutrient Depletion Handbook. Hudson, OH:LexiComp, Inc.;2001:451-454.

Powers HJ. Riboflavin (vitamin B-2) and health. Am J Clin Nutr. 2003;77(6):1352-60.

Quinzii CM, Hirano M, DiMauro S. CoQ10 deficiency diseases in adults. Mitochondrion. 2007;7 Suppl:S122-6.

Rakel. Textbook of Family Medicine, 8th ed. Philadelphia, PA: Saunders Elsevier; 2011.

Young AJ, Johnson S, Steffens DC, Doraiswamy PM. Coenzyme Q10: a review of its promise as a neuroprotectant. CNS Spectr. 2007;12(1):62-8.

Version Info

  • Last Reviewed on 09/28/2012
  • Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed HealthCare Network.

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This page was last updated: May 31, 2013

         
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