Cardiovascular medications - vasodilators

Medications

Depletions

Coenzyme Q10

A deficiency of the antioxidant coenzyme Q10 may be associated with chronic conditions including heart disease and high blood pressure. Symptoms of deficiency include muscular weakness and pain, gingivitis, and weakened immune function.

Magnesium

Magnesium deficiency affects calcium and vitamin D levels in the blood, and may be associated with muscle cramps, heart irregularities, high blood pressure, insomnia, diabetes, and osteoporosis (bone loss).

Vitamin B6 (Pyridoxine)

Symptoms of vitamin B6 deficiency may include weakness, nervousness, insomnia, mental confusion, irritability, and anemia. Chronic low levels of this nutrient may also increase the risk of heart disease, as well as colon and prostate cancers.

Editorial Note

The information presented here covers some of the nutrients that may be affected when you take certain medications. If you have the signs and symptoms listed, it doesn't always mean you have low levels of these nutrients. Many things affect the level of nutrients, including your medical history, diet, and lifestyle, as well as how long you have been taking the medication. Please talk with your health care provider. He or she can best assess your health care needs and determine whether you are at risk for low levels of any nutrients.

Supporting Research

Ames BN. Micronutrient deficiencies: A major cause of DNA damage. Ann NY Acad Sci. 2000;889:87-106.

Bierwirth J, Ulbricht KU, Schmidt RE, Witte T. Association of common variable immunodeficiency with vitamin B(6) deficiency. Eur J Clin Nutr. 2007; [Epub ahead of print].

Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician. 2005;72:1065-70.

Chiang EP, Smith DE, Selhub J, Dallal G, Wang YC, Roubenoff R. Inflammation causes tissue-specific depletion of vitamin B6. Arthritis Res Ther. 2005;7:R1254-62.

Hordyjewska A, Pasternak K. Magnesium role in cardiovascular diseases. Ann Univ Mariae Curie Sklodowska [Med]. 2004;59:108-13.

Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007;37:31-7.

Nielsen FH, Milne DB, Klevay LM, Gallagher S, Johnson L. Dietary magnesium deficiency induces heart rhythm changes, impairs glucose tolerance, and decreases serum cholesterol in post menopausal women. J Am Coll Nutr. 2007;26:121-32.

Pelton R, LaValle J, Hawkins EB, et al. Drug Induced Nutrient Depletion Handbook. Hudson, OH:LexiComp, Inc.;2001:434-435.

Pepe S, Marasco SF, Haas SJ, Sheeran FL, Krum H, Rosenfeldt FL. Coenzyme Q10 in cardiovascular disease. Mitochondrion. 2007;7 Suppl:S154-67.

Powers HJ. Riboflavin (vitamin B-2) and health. Am J Clin Nutr. 2003;77:1352-60.

Quinzii CM, Hirano M, DiMauro S. CoQ10 deficiency diseases in adults. Mitochondrion. 2007;7 Suppl:S122-6.

Rakel. Textbook of Family Medicine, 8th ed. Philadelphia, PA: Elsevier Saunders; 2011.

Rodríguez-Morán M, Guerrero-Romero F. Serum magnesium and C-reactive protein levels. Arch Dis Child. 2007; [Epub ahead of print].

Spinneker A, Sola R, Lemmen V, Castillo MJ, Pietrzik K, González-Gross M. Vitamin B6 status, deficiency and its consequences -- an overview. Nutr Hosp. 2007;22:7-24.

Young AJ, Johnson S, Steffens DC, Doraiswamy PM. Coenzyme Q10: a review of its promise as a neuroprotectant. CNS Spectr. 2007;12:62-8.

Version Info

  • Last reviewed on 9/21/2014
  • Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed HealthCare Network. Also reviewed by the A.D.A.M. Editorial team.

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