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Amcinonide


Pronunciation

 (am SIN oh nide)


U.S. Brand Names

 Cyclocort®


Generic Available

 Yes


Canadian Brand Names

 Amcort®; Cyclocort®


Use

 Relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses (high potency corticosteroid)


Pregnancy Risk Factor

 C


Contraindications

 Hypersensitivity to amcinonide or any component of the formulation; use on the face, groin, or axilla


Warnings/Precautions

 Adverse systemic effects may occur when used on large areas of the body, denuded areas, for prolonged periods of time, with an occlusive dressing, and/or in infants or small children; occlusive dressings should not be used in presence of infection or weeping lesions


Adverse Reactions

 Frequency not defined.

Dermatologic: Acne, hypopigmentation, allergic dermatitis, maceration of the skin, skin atrophy, striae, miliaria, telangiectasia

Endocrine & metabolic: HPA suppression, Cushing's syndrome, growth retardation

Local: Burning, itching, irritation, dryness, folliculitis, hypertrichosis

Systemic: Suppression of HPA axis, Cushing's syndrome, hyperglycemia; these reactions occur more frequently with occlusive dressings

Miscellaneous: Secondary infection


Overdosage/Toxicology

 Symptoms of overdose include cushingoid appearance (systemic), muscle weakness (systemic), osteoporosis (systemic) all with long-term use only. When consumed in excessive quantities for prolonged periods, systemic hypercorticism and adrenal suppression may occur; in those cases, discontinuation and withdrawal of the corticosteroid should be done judiciously.


Drug Interactions

 No data reported


Mechanism of Action

 Stimulates the synthesis of enzymes needed to decrease inflammation, suppress mitotic activity, and cause vasoconstriction


Pharmacodynamics/Kinetics

Absorption: Adequate through intact skin; increases with skin inflammation or occlusion

Metabolism: Hepatic

Excretion: Urine and feces


Dosage

 Topical: Adults: Apply in a thin film 2-3 times/day. Therapy should be discontinued when control is achieved; if no improvement is seen, reassessment of diagnosis may be necessary.


Patient Education

 Before applying, gently wash area to reduce risk of infection; apply a thin film to cleansed area and rub in gently and thoroughly until medication vanishes; avoid exposure to sunlight, severe sunburn may occur


Dental Health: Effects on Dental Treatment

 No significant effects or complications reported


Dental Health: Vasoconstrictor/Local Anesthetic Precautions

 No information available to require special precautions


Mental Health: Effects on Mental Status

 None reported


Mental Health: Effects on Psychiatric Treatment

 None reported


Dosage Forms

Cream: 0.1% (15 g, 30 g, 60 g) [contains benzyl alcohol]

Lotion: 0.1% (60 mL)

Cyclocort®: 0.1% (20 mL, 60 mL) [contains benzyl alcohol]

Ointment: 0.1% (30 g, 60 g) [contains benzyl alcohol]

Cyclocort®: 0.1% (15 g, 30 g, 60 g) [contains benzyl alcohol]


International Brand Names

 Amciderm® (DE, TH); Amcort® (CA); Amicla® (BE, LU); Cyclocort® (CA); Cycloderm® (BE); Visderm® (AR); Visisderm® (TH)


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