Anti-inflammatory medications - 5-Aminosalicylic acid derivatives


5-Aminosalicylic acid derivatives anti-inflammatory medications includes:

Sulfasalazine (Azulfidine EN-tabs and Azulfidine tablets)


Vitamin B9 (Folic Acid)

Low levels of folic acid have been linked to:

  • Anemia
  • Heart disease
  • Birth defects
  • Colon cancer

Symptoms may include fatigue, mouth sores, swollen tongue, depression, and poor growth.

Editorial Note

The information presented here covers some of the nutrients that may be affected when you take certain medications. If you have the signs and symptoms listed, it does not always mean you have low levels of these nutrients. Many things affect the level of nutrients, including your:

  • Medical history
  • Diet
  • Lifestyle

As well as how long you have been taking the medication. Please talk with your health care provider. They can best address your health care needs to determine whether you are at risk for low levels of any nutrients.

Supporting Research

Ames BN. Micronutrient deficiencies: A major cause of DNA damage. Ann NY Acad Sci. 2000;889:87-106.

Jansen G, van der Heijden J, Oerlemans R, et al. Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis. Arthritis Rheum. 2004 Jul;50(7):2130-9.

Pelton R, LaValle J, Hawkins EB, et al. Drug Induced Nutrient Depletion Handbook. Hudson, OH: LexiComp, Inc.;2001:424-425.

Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006;5(11):949-60.

Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA. 2002;288(8):973-9.

Version Info

  • Last reviewed on 8/27/2014
  • Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed HealthCare Network. Also reviewed by the A.D.A.M. Editorial team.

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