Antidepressant medications - selective serotonin reuptake inhibitors (SSRIs)

Selected Medications

Selective serotonin reuptake inhibitors (SSRIs) includes:

Fluoxetine (Prozac, Prozac Weekly, and Sarafem)



Lower levels of melatonin in the body have been linked to:

  • Sleep problems
  • Jet lag

Melatonin may also play a part in keeping your immune system strong.

Proteins and Amino Acids

Not having enough protein can cause a weakened immune system, making you more likely to get an infection and causing wounds to heal slower. It can also lead to muscle and weight loss. In severe cases, it may cause slow growth and skin and hair problems.

Editorial Note

The information presented here covers some of the nutrients that may be affected when you take certain medications. If you have the signs and symptoms listed, it does not always mean you have low levels of these nutrients. Many things affect the level of nutrients, including your:

  • Medical history
  • Diet
  • Lifestyle

As well as how long you have been taking the medication. Please talk with your health care provider. They can best address your health care needs to determine whether you are at risk for low levels of any nutrients.

Supporting Research

Acuna-Castroviejo D, Escames G, Rodriguez MI, Lopez LC. Melatonin role in the mitochondrial function. Front Biosci. 2007;12:947-63.

Altun A, Ugur-Altun B. Melatonin: therapeutic and clinical utilization. Int J Clin Pract. 2007;61(5):835-45.

Lewy AJ, Emens J, Jackman A, Yuhas K. Circadian uses of melatonin in humans. Chronobiol Int. 2006;23(1-2):403-12.

Piccirillo JF. Melatonin. Prog Brain Res. 2007;166:331-3.

Powers HJ. Riboflavin (vitamin B-2) and health. Am J Clin Nutr. 2003;77(6):1352-60.

Reiter RJ. Melatonin: clinical relevance. Best Pract Res Clin Endocrinol Metab. 2003;17(2):273-85.

Version Info

  • Last reviewed on 9/21/2014
  • Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed HealthCare Network. Also reviewed by the A.D.A.M. Editorial team.

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